Several types of master protocol trials can be distinguished, such as basket trials, umbrella trials, and platform trials.
#Seamless designs trial
Master protocol trials allow for the evaluation of both multiple investigational treatments and multiple subgroups of the study population within the same overall clinical trial structure, as compared to traditional randomized controlled trials, where usually only one investigational treatment is investigated in one study population.
#Seamless designs software
We believe that both an open-source modular software similar to OCTOPUS and a collaborative effort will be necessary to create software that takes advantage of and investigates the impact of all the flexibility that platform trials potentially provide. Only a few of the developed software packages provide extensive design flexibility, at the cost of limited access due to being commercial or not being usable as out-of-the-box solutions. In recent years, many highly specialized software packages targeting single design elements on platform studies have been released. The results of this search are reported both on the literature level and the software level, highlighting the software judged to be particularly useful. MethodsĪ systematic search was conducted to review existing software for the design of platform trials, whereby multi-arm multi-stage trials were also included. However, many design-related questions and questions regarding which operating characteristics should be evaluated to determine the potential performance of a specific trial design remain and are often further complicated by the complexity of such trial designs. If you choose to do business with this business, please let the business know that you contacted BBB for a BBB Business Profile.Īs a matter of policy, BBB does not endorse any product, service or business.In recent years, the popularity of multi-arm multi-stage, seamless adaptive, and platform trials has increased. BBB Business Profiles are subject to change at any time. When considering complaint information, please take into account the company's size and volume of transactions, and understand that the nature of complaints and a firm's responses to them are often more important than the number of complaints.īBB Business Profiles generally cover a three-year reporting period. However, BBB does not verify the accuracy of information provided by third parties, and does not guarantee the accuracy of any information in Business Profiles. BBB asks third parties who publish complaints, reviews and/or responses on this website to affirm that the information provided is accurate.
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